|
|
Selected Prognostic and Predictive Factors of Pituitary Tumours in Patients with Acromegaly
Soukup, Jiří ; Ryška, Aleš (advisor) ; Ehrmann, Jiří (referee) ; Fryšák, Zdeněk (referee)
Selected prognostic and predictive factors of pituitary tumours in patients with acromegaly (abstract) Pituitary tumours in patients with acromegaly (somatotroph adenomas, pituitary neuroendocrine tumours - PitNETs) are a rare disease with significant morbidity and high impact on economic resources of the health care system. The surgery is the first line of treatment, and while it cures a subset of the patients, another therapeutical approach combining radiotherapy and pharmacotherapy is needed in the rest. This usually includes treatment with costly somatostatin analogues (SSA). On the opposite, the therapeutic response to SSA is not a rule. This work aimed to perform precise clinicopathological characterisation of available tissue samples of PitNETs in acromegalic patients (n=110) from REgistr SEllárních Tumorů (RESET registry) and further explore potential factors related to clinically aggressive disease phenotype (tumour size, invasion, biochemical parameters) and factors that might predict therapeutic response to the first generation SSA. An extensive immunohistochemical evaluation was performed: tumours were histologically subclassified (expression of cytokeratins, prolactin, TSH) and proliferative activity was assessed (Ki67, p53, mitotic count) as well as expression of possible pharmacological...
|
guest ::
